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The reasons why Europe reviews medications such as Frenadol or Gelocatil Influenza With Pseudoephedrine

The European Medicines Agency (EMA) has put hundreds of medicines containing pseudoephedrine under review, very common in the treatment of diseases such as the cold or flu. The agency’s safety committee has focused on these products for a possible risk of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS), diseases that affect blood vessels in the brain.

Pseudoephedrine is a very common pharmacological agent that is taken orally and is present in some of the best-selling commercial brands in pharmacies. Of the list provided by the EMA of products under surveillance, around thirty are marketed in Spain, some as well-known as Termalgil, Gelocatil Gripe Con Pseudoephedrine, Frenadol Decongestivo or Cinfatós.

These are the medications with pseudoephedrine in Spain:


-Narine Repetabs

-Clarityne Plus

-Lasa With Codeine

-Pseudoephedrine Farmalider

-Gelocatil Influenza With Pseudoephedrine

-Termalgin Cold

-Frenadol Decongestant



-Inistolin Pediatric Cough and Congestion

-Iniston Mucus and Congestion

-Iniston Cough and Congestion

-Grippal With Pseudoephedrine And Dextromethorphan



-Cinfatós Decongestant

-Respidin Expectorant Junior

-Cinfatós Comple



-Anti-allergic Respidin


-Vincigrip Forte Cocoa Flavor

-Vincigrip Forte Orange Flavor


-Virlix Plus

-Ibuprofen/Pseudoephedrine Nutra Essential


-Cortafriol C


According to information released by the European agency, PRES and RCVS cause a reduced blood supply (ischemia) to the brain and can cause serious and life-threatening complications in some cases. Its most common symptoms are headache, nausea and seizures.

Given the risk of these two syndromes, the Medicines Agency will have to decide whether or not to maintain the marketing of these medications, whether they are modified or have to be withdrawn from the market.